Always make sure you have proper redundancy in place. Below are your most impotant considerations.
- Remove SPOF (Single Point Of Failure) – Make sure you have at least two of everything.
- Use shared storage with proper RAID level redundancy.
- Use HA and fault tolerance with multiple hosts in the cluster.
- Use SRM (Site Recovery Manager) to replicate entire production site to DR site or a different branch.
- Make sure your vCenter server is highly available.